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Then researchers proposed that heterozygous knockout mice appeared to be a good animal model for individuals homozygous for the C667T polymorphism, whereas the homozygous null mice were a better one for severely MTHFR-deficient individuals 19

Peters, J., Comparison of Two Methods to Detect Publication Bias in Meta-analysis, JAMA, doi:10.1001/jama.295.6.676

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